I recently have been watching the anime Black Lagoon. It is about a group of mercenary smugglers in an imaginary city named Roanapur in Thailand, set during the 80s. They have a PT boat, and engage in piracy and other unsavory jobs for money.
The main characters are basically action heroes, with many goons to fight. There is a ton of death, but the really talented guys might get shot up and even hurt badly, but are basically safe from true death.
Roanapur is run by the Triads, the Russian mob, La Cosa Nostra, the Colombians, and other smaller groups. It is incredibly dangerous.
It's also the perfect setting for a modern game of something like Shadowrun but without magic, cybernetics, and metahumans. I'd love to see a sourcebook detailing everything.
A system like D6 or even a game based on some of the liter OSR games would probably work perfectly. Heck, using just the base rules of Shadowrun would be ok, though a bit heavier than I prefer these days. Gurps Lite is a good candidate, as well.