It's called Numenera. Looks pretty cool, so far. It's on a future world, with satellites and nanotech still floating around. However, the current civilization is going to be more of a fantasy game. Nano stuff will be seen as magic, and I'm hoping there will be some kind of power armor for fighters.
The game uses the d20, but it certainly doesn't sound like it will be based off of D&D. Your character will have certain abilities that lower target numbers. So far, it sounds like a rules-lite game, which is a big plus in my book.
The art will all be done by one guy, and the sample pieces all look fantastic. I'm betting this game is going to be one gorgeous book. I really hope it's set up and cross-referenced the way Ptolus was. In any case, I'm pretty optimistic. At least he's forging sorta-new ground, instead of pumping out yet another clone.