Just an idea I've had. I love the Dragon Age game (been playing it again), and I think the setting is one of the best fantasy settings going. It appears the Green Ronin version of the game is held up in approval hell (and I wouldn't be surprised if it just fades away).
S&W would be an easy fit. Clerics would be recast as Templars, and Mages would have them watching their every move. It's really a setting for Warriors. I might even want to limit the party to one Mage and one Templar maximum. Not sure if I'd use one of the homebrew thief classes or not.
I'd use orc stats for genlocks, gnoll stats for hurlocks, and add in ogres.Undead pretty much fit right in. Not sure how I'd do demons, though I'd likely just modify an existing creature.
The only special rule I might add is that all characters would be Grey Wardens, and they'd have a 2 in 6 chance of detecting nearby darkspawn.