I'm thinking that the Wilderlands might be a good place to use for the M&M game. The setting is pretty uncivilized compared to many other fantasy worlds, and it has a big minotaur maze and Amazons already included. The hardest part will be porting stuff in. I don't know if anyone has made classes for elfs or dwarfs yet, but I might take a shot at making my own.
I can definitely see the CSIO as a Greek City State, with some fantasy touches. Not sure if I'd leave Viridistan as Greek, or maybe make it Persian or even Stygian. Lots of stuff to think about. If anyone else has already done this, feel free to post a link.